Engineering PTEN-L for Cell-Mediated Delivery
The tumor suppressor Warm-Ups PTEN is frequently inactivated in glioblastoma.PTEN-L is a long form of PTEN produced by translation from an alternate upstream start codon.Unlike PTEN, PTEN-L has a signal sequence and a tract of six arginine residues that allow PTEN-L to be secreted from cells and be taken up by neighboring cells.This suggests that P